Burnley are waiting to discover the extent of the injury suffered by Charlie Taylor in the defeat to Crystal Palace on Saturday.
The left back was forced off with a hamstring problem in the first half at Turf Moor with Erik Pieters coming on in his place.
Taylor suffered an injury in pre-season which led to Pieters starting the campaign as first choice at left back.
But the former Leeds United man came into the side ahead of the win over West Ham and Burnley have not conceded a goal while Taylor has been on the pitch this season.
The 26-year-old was able to walk off at Turf Moor on Saturday but must be considered a major doubt for the visit of Man City on Tuesday night.
“We will wait and see,” said Dyche. “It’s a hamstring but I don’t know to what extent.
“He has done well and was looking strong before he came off and we will wait and see, I don’t know how bad his injury is at the moment.”
Should Taylor miss out then Pieters will step in against the champions.
Meanwhile, Danny Drinkwater is now considered 100 per cent fit after he made a Premier League matchday squad for the first time since August.
He didn’t get off the bench against the Eagles, with Jeff Hendrick preferred in the middle of midfield, but Dyche has no concerns over the Chelsea loanee’s fitness.
“It was tight call but Jeff has done ever so well for us so I felt as though Jeff should go into midfield for us.”
Matej Vydra did not make the 18 despite recovering from a hip problem that kept him out for two weeks with Dyche adding: “He has only trained the last few days so he is back in the thinking.”
Burnley will remain without Johann Berg Gudmundsson, who continues to recover from a hamstring problem, for the visit of Man City but will welcome Ashley Westwood back from suspension.